Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity
نویسندگان
چکیده
منابع مشابه
Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity.
OBJECTIVE YKL-40, also called human cartilage glycoprotein-39, is secreted by chondrocytes, synovial cells, macrophages and neutrophils. Studies have shown that YKL-40 is an autoantigen in rheumatoid arthritis (RA). We evaluated whether serum YKL-40 was related to disease activity in patients with RA. METHODS Serum YKL-40 was determined by radioimmunoassay in 156 patients with RA during a 1 y...
متن کاملSerum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis
Background: The present study aimed to evaluate serum YKL-40 levels in patients with rheumatoid arthritis (RA) compared to healthy subjects and to search whether there is an association between YKL-40 levels and disease characteristics in RA. Methods: In this cross-sectional study, 60 RA patients based on the ACR/EULAR 2010 criteria and 30 age- and sex-matched healthy controls were included. I...
متن کاملSerum YKL-40 concentrations in patients with early rheumatoid arthritis: relation to joint destruction.
OBJECTIVE YKL-40 is a secretory glycoprotein of chondrocytes, synovial cells, macrophages, and neutrophils. The aims were to determine serum YKL-40 in patients with early rheumatoid arthritis (RA) and seek associations with early joint erosions. METHODS YKL-40 was measured by ELISA in serum samples collected every three month for 36 months from patients with early RA. The patients were treate...
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Background and Objective: Rheumatoid arthritis (RA) is an autoimmune disease defined by chronic synovitis and progressive joint destruction. This study investigated calprotectin as a serological marker in the hope of establishing an adequate means of diagnosing RA and following up on patients. Materials and Methods: This cross-sectional study included 32 RA patients who were referred to the rh...
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BACKGROUND YKL-40 is secreted by macrophages and neutrophils and is a growth factor for vascular endothelial cells and fibroblasts. Elevated serum concentrations of YKL-40 are found in patients with diseases characterized by inflammation or ongoing fibrosis. The aim of this study was to seek association between serum YKL-40 in patients with ulcerative colitis (UC) and Crohn disease (CD) and cli...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 1999
ISSN: 1460-2172
DOI: 10.1093/rheumatology/38.7.618